Job Description

Job Description
(Required): Why Patients Need You
***'s purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling ***'s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.


What You Will Achieve


Manufacturing Sciences and Technology (MSAT) Upstream Group at *** is looking for a highly motivated and versatile candidate to join our multidisciplinary team of scientists and engineers in Andover, MA. MSAT supports ***'s portfolio of late-stage development of commercial biopharmaceuticals and vaccines, and is responsible for process troubleshooting, process improvements and second- generation process development. We are looking for someone who is eager to contribute independent thinking and technical excellence to the upstream fermentation team.


The Scientist will be a part of a diverse and motivated team of scientists, engineers, and technical professionals that are focused on fermentation processes to produce biotherapeutics. The role is well-integrated into the rest of the MSAT Microbial Team. This role will collaborate with other MSAT scientists to setup bioreactors and execute well-designed experiments, including but not limited to basic analytics, data acquisition and documentation of work. The candidate would also be responsible for user-level maintenance of the relevant equipment and associated documentation.


How You Will Achieve It


ROLE RESPONSIBILITIES
• Plan and execute upstream process experiments at benchtop scales
• Participates and significantly contributes to discussions in lab and project team meetings on design of experiments (bioreactor and shake flask) and interpretation of experimental data.
• Acts as a technical resource within the upstream group. Provides formal/informal mentoring to junior colleagues within work group/project team.
• Works under limited supervision with periodic review of achievement of results and experimental approaches employed. Manages own time to meet agreed targets. Develops plans for short-term work activities on own projects.
• Ensures effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks and internal technical reports; presents data/ strategy to scientists and management in appropriate internal and external venues (technical meetings, project team meetings, conferences) as appropriate.
• Contributes to safe, efficient, effective and harmonious lab environment, ensures appropriate cleanliness and status/ operability of shared or assigned lab space or equipment; strong lab citizen and collaborative team player; approaches the job with energy and commitment; frequently demonstrates initiative.
• Participate in multi-disciplinary teams to resolve complex issues
• Assist in manufacturing investigations and process troubleshooting
• Assist on process improvement projects
Qualifications
Required
• Ph. D. with 0-4 years of experience in biotechnology Master's degree in a relevant discipline with at 3-5 years of applicable bioprocess experience or bachelor's degree with at least 7 years of experience
• Proficient in aseptic technique (required)
• Proficient in benchtop bioreactor operation and associated analytical tools (required)
• Experience with bench scale cell culture and/or bacterial fermentation (required)
• An in-depth knowledge of bioreactor operations fed-batch, perfusion, and continuous modes of cell culture
• Strong trouble-shooting skills and extreme attention to detail required
• Ability to troubleshoot technical issues, plan and carry out experiments independently, and work with complex instrumentation and software.
• Excellent oral and written communication skills.
• Strong analytical and computer skills.


Preferred
• Prior experience developing and maintaining scale down models of commercial biopharmaceutical processes
• Prior experience in developing commercially relevant cell culture processes to produce pharmacologically active proteins
• Experience with control and data acquisition systems
• Demonstrated experience developing or introducing new technology into commercial processes
• Knowledge of all aspects of cell culture/fermentation, including batch, fed-batch, perfusion and harvest/clarification operations
• Familiarity with DoE and other statistical tools
• Experience with processing and interpreting large data sets
• Familiarity with regulatory filings, cGMP requirements and operational constraints


PHYSICAL/MENTAL REQUIREMENTS
• Involves typical bioprocessing lab activities
• Ability to routinely lift 50 lbs.
• Standing for prolonged periods of time, walking, bending, and using tools.
• Ability to perform mathematical calculations and ability to perform complex data analysis.


NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
• Requires off hours working to support laboratory work on average of two times per week.
• This is an on-site laboratory role.


Daily Schedule: Monday - Friday / First Shift


Interview: First Round: Teams, Second Round: Onsite
Position Comments visible to Supplier: Candidates must be able to speak to true job experience.

Job Tags

Temporary work, Day shift, Monday to Friday,

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